Note: This is assuming you will be dropping two or more items for each boss.
Artemis is God of the hunt as well, why not give her a Trap? They can’t really share a bow, as they’re two different gods, so allow them to drop two different mid-tier bows that you can combine to make a ‘Bow of Twilight’.
Ares Boss should have high attack, and very sporadic phases, but low health (like the warrior itself). The Helm he drops should give both Damaging, Speedy, and Beserk to Self only, but should also give the user vulnerability (takes extra damage) and a high CD. The Sword should be something with short range, but a high projectile speed and damage (Above Acclaim, below A.S.S). The Sword should also come with a subtraction of Defense and/or Health, really bringing forth the whole glass-canon feel.
Poseidon is a bit confusing, while I agree that in theory, it should be a perfect match, as Wizards use the elements to their advantage as well, I have no idea how to implement a spell bomb for him in a way that makes sense. The trident being a staff is an excellent idea, however. I imagine it ignoring defence and hitting multiple targets, but having about as much damage as a t10 Staff. But I definitely think that the other item he should drop should be a spell of some sort.
Zeus’ Thunderbolt would have to literally be overpowered, as he is Zeus, king of the gods. I imagine that its weakness would be that it can only be used at a close range, with a cooldown that makes you unable to spam it. The other thing he should drop would be a ring, as in true ROTMG fashion, the big boss always drops a ring. It should be a jack of all trades, master of none, but providing enough decent stats so that you won’t feel bad about replacing your Deca with it.
Hera being the Goddess of Magic should drop a Robe and a magical weapon, as she is the Goddess of Magic, I think that the weapon itself should be capable of going on any of the robe classes, being the Dbow of robe classes. As being the Goddess of Magic means that she is a godly enchanter, it’s likely that anything she makes needs to be op to fit with lore.
That brings me to my other point, Hephastus. Since the guy is literally the smith of the gods, you have a dilemma with any items he makes. So I think that it’s a good idea that you’d make it so that he would drop something for a Knight, as a Knight with OP items is still a Knight (50 Att, 50 Dex, still won’t do much with an OP Shield and OP Armor, other than survive). The shield should definitely be an Ogmur-rival/direct upgrade to Ogmur, that also stuns, the set-back, once again, is that a mortal is playing with a god’s tools, thus a high cooldown and mp-cost, meaning that you have to make those 5 shots count. The Armor should be a direct upgrade to Acrop, maybe sporting an attack and Health Buff with a speed and dex downgrade, as when it was designed for a god to wear it, not taking in the fact that it is very heavy to a mortal. So even though the armor is amazing, using it in a Tomb will likely get you stuck in the sand, with no ability to get out quickly as Geb is rushing towards you, no matter the 90 Def you have, you will still get popped.
Necro skull should give self-buff of invisibility and speedy, but also darkness. Not sure about anything else, though, we already have plenty Robes and Staffs at this point. So maybe change it to a Ninja that remains invisible as long as you’re holding down the space bar? This allows Speedy without making it too ridiculous for Necro.
As Hermes is the God of theives, the whole Rouge thing makes sense.