Oryx Runes are a collection of three special dungeon keys that will need to be used to unlock the entrance to Oryx’s Sanctuary and face Oryx the Mad God 3. The locked dungeon portal is planned to appear after defeating Oryx the Mad God 2 in the Wine Cellar.
Oryx’s Sanctuary is still in development, but the Runes were “pre-released” in Event Chests during the Realm of the Mad God Exalt open beta.
The Runes do not drop yet, but their drop locations have been laid out:
Each rune has 750 feed power and is soulbound.